Fortuyn Hal A Droogleever, Swinkels Sofie, Buitelaar Jan, Renier Wily O, Furer Joop W, Rijnders Cees A, Hodiamont Paul P, Overeem Sabastiaan
Department of Psychiatry, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Sleep. 2008 Mar;31(3):335-41. doi: 10.1093/sleep/31.3.335.
To study the prevalence of and symptoms of eating disorders in patients with narcolepsy.
We performed a case-control study comparing symptoms of eating disorders in patients with narcolepsy versus healthy population controls, using the Schedules for Clinical Assessment in Neuropsychiatry (SCAN 2.1). To study whether an increased body mass index (BMI) could be responsible for symptoms of an eating disorder, we also compared patients with BMI-matched controls, using the SCAN as well as the Eating Disorder Examination-Questionnaire.
University hospital.
Patients with narcolepsy/cataplexy (n = 60) were recruited from specialized sleep centers. Healthy controls (n = 120) were drawn from a population study previously performed in the Netherlands. Separately, 32 BMI-matched controls were recruited.
N/A.
In total, 23.3% of the patients fulfilled the criteria for a clinical eating disorder, as opposed to none of the control subjects. Most of these were classified as Eating Disorder-Not Otherwise Specified, with an incomplete form of binge eating disorder. On the symptom level, half of the patients reported a persistent craving for food, as well as binge eating. Twenty-five percent of patients even reported binging twice a week or more often. When compared with BMI-matched controls, the significant increases persisted in symptoms of eating disorders among patients with narcolepsy. Except for a higher level of interference in daily activities due to eating problems in patients using antidepressants, medication use did not influence our findings.
The majority of patients with narcolepsy experience a number of symptoms of eating disorders, with an irresistible craving for food and binge eating as the most prominent features. Eating disorder symptomatology interfered with daily activities. These findings justify more attention for eating disorders in the treatment of patients with narcolepsy.
研究发作性睡病患者中饮食失调的患病率及症状。
我们进行了一项病例对照研究，使用神经精神病学临床评估量表（SCAN 2.1）比较发作性睡病患者与健康人群对照中饮食失调的症状。为研究体重指数（BMI）升高是否可能导致饮食失调症状，我们还使用SCAN以及饮食失调检查问卷，将患者与BMI匹配的对照进行了比较。
大学医院。
发作性睡病/猝倒症患者（n = 60）从专门的睡眠中心招募。健康对照（n = 120）来自之前在荷兰进行的一项人群研究。另外，招募了32名BMI匹配的对照。
无。
总体而言，23.3%的患者符合临床饮食失调的标准，而对照受试者无一符合。其中大多数被归类为未特定指明的饮食失调，具有不完全形式的暴饮暴食症。在症状层面，一半的患者报告持续渴望食物以及暴饮暴食。25%的患者甚至报告每周暴饮暴食两次或更频繁。与BMI匹配的对照相比，发作性睡病患者中饮食失调症状仍显著增加。除了使用抗抑郁药的患者因饮食问题对日常活动的干扰程度较高外，药物使用并未影响我们的研究结果。
大多数发作性睡病患者经历多种饮食失调症状，对食物的无法抗拒的渴望和暴饮暴食是最突出的特征。饮食失调症状干扰了日常活动。这些发现表明在发作性睡病患者的治疗中应更多关注饮食失调问题。
