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Selective synthesis of 4-alkylidene-beta-lactams and N,N'-diarylamidines from azides and aryloxyacetyl chlorides via a ketenimine-participating one-pot cascade process.

作者信息

Yang Yun-Yun, Shou Wang-Ge, Hong Deng, Wang Yan-Guang

机构信息

Department of Chemistry, Zhejiang University, Hangzhou 310027, China.

出版信息

J Org Chem. 2008 May 2;73(9):3574-7. doi: 10.1021/jo702733h. Epub 2008 Mar 26.

DOI:10.1021/jo702733h
PMID:18363365
Abstract

A one-pot cascade approach to 4-alkylidene-beta-lactams and N, N'-diarylamidines from aryl azides and aryloxyacetyl chlorides has been developed. The chemical outcome of the reaction can be controlled selectively by an appropriate choice of the stoichiometric ratio of different substrates and reagents. The products should find use in pharmaceutical discovery, especially in the development of new antimicrobial agents against multidrug-resistant pathogens.

摘要

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