Grodums E I
Arch Virol. 1976;51(1-2):75-85. doi: 10.1007/BF01317836.
The ultrastructure of the periventricular and choroid plexus tissues was studied in the three-week-old mouse, infected with the vesicular stomatitis virus (VSV) by the intranasal route. The VSV reached the periventricular ependymal lining late in infection. It was carried within the cytoplasm of myelinated axons and their sheath cells. Inflammatory cells, although few in numbers, may have also contributed to the virus dissemination. Once in the periventricular tissues the VSV entered the cells from the intercellular space. It replicated in both the ependymal and subependymal cells. It matured either directly in the cytoplasm, or by budding from the plasmalemma as well as the cytoplasmic membranes. In numerous cells the cytoplasmic membranes formed the so-called undulating tubules which contained the VSV particles. The infected ependymal cells became necrotic and separated from the ventricular surface. The changes were similar in all three of the cerebral ventricles. At no time during the infection was the VSV observed near or within any of the choroid plexuses. Some ultrastructural changes, however, occurred in the choroidal epithelial cells. These may have developed either as a consequence of viral damage in the periventricular tissues, or due to virus presence in the cerebral ventricles.
对经鼻途径感染水泡性口炎病毒（VSV）的三周龄小鼠的脑室周围组织和脉络丛组织的超微结构进行了研究。VSV在感染后期到达脑室周围室管膜内衬。它存在于有髓轴突及其鞘细胞的细胞质中。炎性细胞数量虽少，但可能也促进了病毒传播。一旦进入脑室周围组织，VSV就从细胞间隙进入细胞。它在室管膜细胞和室管膜下细胞中复制。它要么直接在细胞质中成熟，要么通过从质膜以及细胞质膜出芽而成熟。在许多细胞中，细胞质膜形成了含有VSV颗粒的所谓起伏小管。被感染的室管膜细胞发生坏死并从脑室表面分离。所有三个脑室中的变化都是相似的。在感染期间的任何时候，都未在任何脉络丛附近或内部观察到VSV。然而，脉络丛上皮细胞发生了一些超微结构变化。这些变化可能是脑室周围组织中病毒损伤的结果，也可能是由于脑室中存在病毒所致。
