Taylor Mark, Shajahan Polash, Lawrie Stephen M
Springpark Centre, Glasgow, United Kingdom.
J Clin Psychiatry. 2008 Feb;69(2):240-5. doi: 10.4088/jcp.v69n0210.
There are few independent studies comparing atypical or second-generation antipsychotics (SGAs).
To compare the patterns of use and discontinuation of commonly used SGAs.
Retrospective review of 11,250 case records (2002-2005) of all mental health care contacts in a discrete geographical setting in Scotland. Patterns of use, mean dose, psychotropic co-prescription, duration of treatment, discontinuation rates, and admission rates were examined for amisulpride, clozapine, olanzapine, quetiapine, and risperidone.
Clozapine had a significantly lower discontinuation rate in individuals with schizophrenia, compared to the other 4 SGAs. Off-license prescribing and polypharmacy were common.
SGAs are variously used for schizophrenia and mood disorder and have heterogeneous outcomes, with clozapine being most effective in this study. Independent observational studies such as this complement randomized controlled trials.
比较非典型或第二代抗精神病药物（SGA）的独立研究较少。
比较常用SGA的使用模式和停药情况。
对苏格兰一个特定地理区域内2002年至2005年所有心理健康护理接触的11250例病例记录进行回顾性研究。对氨磺必利、氯氮平、奥氮平、喹硫平和利培酮的使用模式、平均剂量、精神药物联合处方、治疗持续时间、停药率和住院率进行了检查。
与其他4种SGA相比，氯氮平在精神分裂症患者中的停药率显著较低。超说明书用药和联合用药很常见。
SGA在精神分裂症和情绪障碍中有着不同的用途，且结果各异，在本研究中氯氮平最为有效。此类独立观察性研究可补充随机对照试验。
