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Interlinked fast and slow positive feedback loops drive reliable cell decisions.相互关联的快速和慢速正反馈回路驱动可靠的细胞决策。
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Bistability in cell signaling: How to make continuous processes discontinuous, and reversible processes irreversible.细胞信号传导中的双稳态：如何使连续过程变为不连续，以及可逆过程变为不可逆。
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Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2.构建细胞周期振荡器：Cdc2激活过程中的滞后现象和双稳性
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Phosphorylation of isocitrate dehydrogenase as a demonstration of enhanced sensitivity in covalent regulation.异柠檬酸脱氢酶的磷酸化作为共价调节中敏感性增强的一种表现。
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Feedback regulation of opposing enzymes generates robust, all-or-none bistable responses.

作者信息

Ferrell James E

出版信息

Curr Biol. 2008 Mar 25;18(6):R244-5. doi: 10.1016/j.cub.2008.02.035.

DOI:10.1016/j.cub.2008.02.035
PMID:18364225
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2832910/
Abstract
摘要