磷脂酰肌醇磷酸4-激酶2α对核外磷脂酰肌醇5-磷酸生成的调控
Regulation of extranuclear PtdIns5P production by phosphatidylinositol phosphate 4-kinase 2alpha.
作者信息
Wilcox Andrew, Hinchliffe Katherine A
机构信息
The University of Manchester, Faculty of Life Sciences, Manchester M13 9NT, UK.
出版信息
FEBS Lett. 2008 Apr 16;582(9):1391-4. doi: 10.1016/j.febslet.2008.03.022. Epub 2008 Mar 24.
Cellular levels of the phosphoinositide PtdIns5P are regulated by agonist stimulation, but the mechanisms controlling turnover of this lipid, and the subcellular location of the regulated PtdIns5P pool(s), remain poorly understood. Here we show that enhanced tyrosine phosphorylation robustly increases cellular PtdIns5P levels. Moreover, unlike PtdIns5P production enhanced by cell stress, we show that this pool of PtdIns5P is specifically regulated by the inositol lipid kinase PIP4K2a.
磷酸肌醇PtdIns5P的细胞水平受激动剂刺激调节，但其脂质周转的控制机制以及受调节的PtdIns5P池的亚细胞定位仍知之甚少。在此我们表明，酪氨酸磷酸化增强会显著提高细胞内PtdIns5P水平。此外，与细胞应激增强PtdIns5P的产生不同，我们发现这一PtdIns5P池受肌醇脂质激酶PIP4K2a特异性调节。
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