PtdIns5P：出现、消失和行为的新观点。
PtdIns5P: news and views of its appearance, disappearance and deeds.
机构信息
Department of Physiology, Wayne State University School of Medicine, 540 E. Canfield, Detroit, MI 48201, United States.
出版信息
Arch Biochem Biophys. 2013 Oct 15;538(2):171-80. doi: 10.1016/j.abb.2013.07.023. Epub 2013 Aug 2.
Abstract
Accumulated evidence indicates that PtdIns5P, one of the seven phosphoinositides, found now to be constitutively present in yeast, plants and metazoa, serves as a signaling molecule to modulate pleiotropic cellular functions in both the nucleus and the cytoplasm. The enzymatic routes in biogenesis of basal PtdIns5P have remained incompletely understood. The role for candidate kinase PIKfyve that is principally involved in PtdIns(3,5)P2 production, has been questioned. In this review article we scrutinize the past obstacles that prevented the definitive implication of PIKfyve in PtdIns5P biosynthesis from PtdIns and focus on the recent pharmacological and genetic advancements that now make this conclusion well supported. We further summarize our current knowledge of the diverse stimuli modulating PtdIns5P levels, binding partners and regulated cellular process, with particular reference to the available mechanistic insights for the relevant signaling pathways.
摘要
积累的证据表明，磷脂酰肌醇 5-磷酸（PtdIns5P）是七种磷酸肌醇之一，现已在酵母、植物和后生动物中普遍存在，作为一种信号分子调节细胞核和细胞质中多种细胞功能。基础 PtdIns5P 生物发生的酶途径仍不完全清楚。候选激酶 PIKfyve 主要参与 PtdIns(3,5)P2 的产生，其作用一直受到质疑。在这篇综述文章中，我们仔细研究了过去阻碍 PIKfyve 将 PtdIns 和 PtdIns5P 生物合成明确联系起来的障碍，并重点介绍了最近的药理学和遗传学进展，这些进展现在为这一结论提供了充分的支持。我们进一步总结了我们目前对调节 PtdIns5P 水平、结合伴侣和受调控细胞过程的各种刺激的了解，特别参考了相关信号通路的现有机制见解。
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