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新型巴西副球孢子菌分离株揭示了这种人类病原体意想不到的基因组变异性。

New Paracoccidioides brasiliensis isolate reveals unexpected genomic variability in this human pathogen.

作者信息

Carrero Lilia L, Niño-Vega Gustavo, Teixeira Marcus M, Carvalho Maria Jose A, Soares Célia M A, Pereira Maristela, Jesuino Rosália S A, McEwen Juan G, Mendoza Leonel, Taylor John W, Felipe Maria Sueli, San-Blas Gioconda

机构信息

Instituto Venezolano de Investigaciones Científicas, Laboratorio de Micología, P.O. Box 21827, Caracas, Venezuela.

出版信息

Fungal Genet Biol. 2008 May;45(5):605-12. doi: 10.1016/j.fgb.2008.02.002. Epub 2008 Feb 21.

DOI:10.1016/j.fgb.2008.02.002
PMID:18364259
Abstract

By means of genealogical concordance phylogenetic species recognition (GCPSR), we have investigated coding and non-coding regions from various genes and the ITS sequences of 7 new and 14 known isolates of Paracoccidioides brasiliensis. Such isolates grouped within the three phylogenetic groups recently reported in the genus Paracoccidioides, with one single exception, i.e., Pb01, a strain that has been the subject of intense molecular studies for many years. This isolate clearly separates from all other Paracoccidioides isolates in phylogenetic analyses and greatly increases the genomic variation known in this genus.

摘要

通过系谱一致性系统发育物种识别(GCPSR),我们研究了巴西副球孢子菌7株新分离株和14株已知分离株的各种基因的编码区和非编码区以及ITS序列。这些分离株归入副球孢子菌属最近报道的三个系统发育组中,只有一个例外,即Pb01菌株,多年来它一直是深入分子研究的对象。在系统发育分析中,该分离株明显与所有其他副球孢子菌分离株分开,大大增加了该属已知的基因组变异。

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