Kim Geun Hyung, Min Taijin, Park Su A, Kim Wan Doo
Nature-Inspired Bio-Mechanical Team, Division of Nano-Machinery, Korea Institute of Machinery and Materials, 171 Jang-dong, Yuseong-gu, Daejeon 305-343, South Korea.
Bioinspir Biomim. 2008 Mar;3:016006. doi: 10.1088/1748-3182/3/1/016006. Epub 2008 Mar 10.
Eggshell membrane (ESM) has potential as a natural scaffold because of its highly porous structure and good biocompatibility. To mimic its structure and surface properties, soluble eggshell membrane protein (SEP) was extracted from ESM and electrospun with a biodegradable polymer, poly(epsilon-caprolactone) (PCL). SEP/PCL micro/nanofibers were fabricated using a coaxial electrospinning process with a dual nozzle and an auxiliary cylindrical electrode. The fiber web was characterized using the water contact angle, pore-size distribution, mechanical properties and cellular behavior. The SEP/PCL web, which demonstrated the feasibility of producing a scaffold with adequate hydrophilicity, suitable pore size and good mechanical properties compared to a pure PCL micro/nanofiber web, exhibits the ability to mimic a natural biomaterial.
蛋壳膜（ESM）因其高度多孔的结构和良好的生物相容性而具有作为天然支架的潜力。为了模拟其结构和表面特性，从蛋壳膜中提取了可溶性蛋壳膜蛋白（SEP），并与可生物降解聚合物聚（ε-己内酯）（PCL）进行电纺。采用带有双喷嘴和辅助圆柱形电极的同轴电纺工艺制备了SEP/PCL微/纳米纤维。使用水接触角、孔径分布、力学性能和细胞行为对纤维网进行了表征。与纯PCL微/纳米纤维网相比，SEP/PCL网具有产生具有足够亲水性、合适孔径和良好力学性能的支架的可行性，展现出模拟天然生物材料的能力。
