Kappel C A, Dal Canto M C, Melvold R W, Kim B S
Tumor Cell Biology Program, Northwestern University Medical School, Chicago, IL 60611.
J Immunol. 1991 Dec 15;147(12):4322-6.
Intracerebral inoculation of susceptible mice with Theiler's murine encephalomyelitis virus induces a demyelinating disease that is similar to human multiple sclerosis. This murine model for human multiple sclerosis is apparently immune-mediated and the genes involved in the immune response influence the outcome of disease susceptibility as observed with human multiple sclerosis. These genes include the MHC and TCR genes. However, the functional relationships among these genes on the disease susceptibility has not yet been studied. In this study, we demonstrate that the effect of the H-2s genotype from susceptible SJL/J mice overrides the resistant effect of the BALB/c TCR beta-chain gene in CXJ recombinant-inbred and BALB.S congenic mice. These results strongly suggest the presence of a hierarchy of genes involved in the immune response in Theiler's murine encephalomyelitis virus-induced demyelinating disease.
用泰勒氏鼠脑脊髓炎病毒对易感小鼠进行脑内接种会引发一种脱髓鞘疾病，该疾病与人类多发性硬化症相似。这种人类多发性硬化症的小鼠模型显然是免疫介导的，并且正如在人类多发性硬化症中所观察到的那样，参与免疫反应的基因会影响疾病易感性的结果。这些基因包括主要组织相容性复合体（MHC）和T细胞受体（TCR）基因。然而，这些基因之间关于疾病易感性的功能关系尚未得到研究。在本研究中，我们证明，在CXJ重组近交系小鼠和BALB.S同源基因小鼠中，来自易感SJL/J小鼠的H-2s基因型的作用超过了BALB/c TCRβ链基因的抗性作用。这些结果有力地表明，在泰勒氏鼠脑脊髓炎病毒诱导的脱髓鞘疾病中，存在参与免疫反应的基因层次结构。
