Kishimoto T
Department of Clinical Investigation Kure Kyosai Hospital, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1991 Sep;29(9):1168-73.
The distribution of various oncogenes in the tumor tissues of 8 cases of malignant mesothelioma related to asbestos exposure was evaluated by monoclonal antibodies against oncogenes. There was no staining for K-ras, H-ras and erb-B in all cases and C-abl slightly stained in only one case of a biphasic type of tumor. On the other hand, C-myc positively stained in epithelioid type and the epitheloidal portion of the biphasic type of tumors. C-neu, C-fos and N-myc positively stained in almost all cases. Of these 9 oncogenes, C-neu was most frequently stained in all cases. These results suggest that C-myc, N-myc, C-neu and C-fos oncogenes may have some role in the appearance of malignant mesothelioma related to asbestos exposure.
采用针对癌基因的单克隆抗体，评估了8例与石棉暴露相关的恶性间皮瘤肿瘤组织中各种癌基因的分布情况。所有病例中K-ras、H-ras和erb-B均无染色，仅1例双相型肿瘤中C-abl有轻微染色。另一方面，C-myc在上皮样型及双相型肿瘤的上皮样部分呈阳性染色。C-neu、C-fos和N-myc在几乎所有病例中均呈阳性染色。在这9种癌基因中，C-neu在所有病例中染色最为频繁。这些结果表明，C-myc、N-myc、C-neu和C-fos癌基因可能在与石棉暴露相关的恶性间皮瘤的发生中发挥一定作用。
