间皮瘤中的癌基因与肿瘤抑制基因——概述
Oncogenes and tumor-suppressor genes in mesothelioma--a synopsis.
作者信息
Lechner J F, Tesfaigzi J, Gerwin B I
机构信息
Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA.
出版信息
Environ Health Perspect. 1997 Sep;105 Suppl 5(Suppl 5):1061-7. doi: 10.1289/ehp.97105s51061.
Abstract
Invariably mesothelioma is diagnosed late in the development of the disease when treatment is no longer effective. Therefore, a key to reducing the mortality rate of this neoplasm is knowledge of the general sequence of genetic events between initiation of mesothelial cells and the emergence of the metastatic tumor cells. Unfortunately, relatively little is known about the early changes in the genesis of this disease. Of the known changes, the most frequent are in the tumor-suppressor genes p16INK4a and NF2 and possibly the SV40 virus large T-antigen oncogene. The molecular nature of the changes in these genes as well as other alterations are addressed in this overview.
摘要
间皮瘤往往在疾病发展后期才被诊断出来，此时治疗已不再有效。因此，降低这种肿瘤死亡率的关键在于了解间皮细胞起始与转移性肿瘤细胞出现之间基因事件的一般顺序。不幸的是，对于这种疾病发生过程中的早期变化了解相对较少。在已知的变化中，最常见的是肿瘤抑制基因p16INK4a和NF2的变化，以及可能的SV40病毒大T抗原癌基因的变化。本综述将探讨这些基因变化以及其他改变的分子本质。
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