DNA与含有不对称配体的钌（II）多吡啶配合物的相互作用。
DNA interactions with ruthenium(ll) polypyridine complexes containing asymmetric ligands.
作者信息
Chao Hui, Ji Liang-Nian
机构信息
Department of Chemistry, The Key laboratory of Gene Engineering of Ministry of Eduction, Sun Yat-Sen University, Guangzhou 510275, China.
出版信息
Bioinorg Chem Appl. 2005;3(1-2):15-28. doi: 10.1155/BCA.2005.15.
In an attempt to probe nucleic acid structures, numerous Ru(II) complexes with different ligands have been synthesized and investigated. In this contribution we focus on the DNA-binding properties of ruthenium(II) complexes containing asymmetric ligands that have attracted little attention in the past decades. The influences of the shape and size of the ligand on the binding modes, affinity, enantioselectivities and photocleavage of the complexes to DNA are described.
为了探究核酸结构，人们已经合成并研究了许多带有不同配体的钌（II）配合物。在本论文中，我们聚焦于含有不对称配体的钌（II）配合物的DNA结合特性，这类配合物在过去几十年中很少受到关注。本文描述了配体的形状和大小对配合物与DNA的结合模式、亲和力、对映选择性和光切割作用的影响。
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