Liu XueWen, Li ZhiXin, Hu Xia, Zhang SongBai, Lu JiLin
a College of Chemistry and Chemical Engineering , Hunan University of Arts and Science , ChangDe , P.R. China.
Nucleosides Nucleotides Nucleic Acids. 2014;33(8):519-35. doi: 10.1080/15257770.2014.900183.
A new asymmetry ligand pibi (pibi = 2-(pyridine-2-yl)-1-H-imidazo[4,5-f]benzo[d]imidazolone) and its ruthenium complexes with Ru(L)2(pibi) (L = bpy (2, 2'-bipyridine), phen (1, 10-phenanthroline)), have been synthesized and characterized. The binding of two complexes with calf thymus DNA has been investigated by spectroscopic and viscosity measurement. The results indicate that both complexes can bind to CT-DNA through intercalative mode. Under irradiation at 365 nm, both complexes can partly promote the photocleavage of plasmid pBR322DNA. The low singlet oxygen generation abilities of the two complexes may be the factor for the low DNA photocleavage abilities.
一种新型不对称配体pibi（pibi = 2-(吡啶-2-基)-1-H-咪唑并[4,5-f]苯并[d]咪唑酮）及其钌配合物Ru(L)2(pibi)（L = bpy（2,2'-联吡啶），phen（1,10-菲咯啉））已被合成并表征。通过光谱和粘度测量研究了这两种配合物与小牛胸腺DNA的结合。结果表明，两种配合物均能通过插入模式与CT-DNA结合。在365 nm光照下，两种配合物均能部分促进质粒pBR322DNA的光裂解。两种配合物单线态氧生成能力较低可能是其DNA光裂解能力较低的原因。
