Hua-Lian Hang, Qiang Xia, Department of Liver Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China.
World J Gastroenterol. 2014 Jan 7;20(1):126-32. doi: 10.3748/wjg.v20.i1.126.
Hepatocellular carcinoma (HCC), which develops from liver cirrhosis, is highly prevalent worldwide and is a malignancy that leads to liver failure and systemic metastasis. While surgery is the preferred treatment for HCC, intervention and liver transplantation are also treatment options for end-stage liver disease. However, the success of partial hepatectomy and intervention is hindered by the decompensation of liver function. Conversely, liver transplantation is difficult to carry out due to its high cost and the lack of donor organs. Fortunately, research into bone-marrow stromal cells (BMSCs) has opened a new door in this field. BMSCs are a type of stem cell with powerful proliferative and differential potential that represent an attractive tool for the establishment of successful stem cell-based therapy for liver diseases. A number of different stromal cells contribute to the therapeutic effects exerted by BMSCs because BMSCs can differentiate into functional hepatic cells and can produce a series of growth factors and cytokines capable of suppressing inflammatory responses, reducing hepatocyte apoptosis, reversing liver fibrosis and enhancing hepatocyte functionality. Additionally, it has been shown that BMSCs can increase the apoptosis rate of cancer cells and inhibit tumor metastasis in some microenvironments. This review focuses on BMSCs and their possible applications in liver regeneration and metastasis after hepatectomy.
肝细胞癌（HCC）源于肝硬化，在全球范围内高发，是导致肝衰竭和全身转移的恶性肿瘤。尽管手术是 HCC 的首选治疗方法，但介入治疗和肝移植也是终末期肝病的治疗选择。然而，部分肝切除术和介入治疗的成功受到肝功能失代偿的阻碍。相反，由于成本高和供体器官缺乏，肝移植难以进行。幸运的是，骨髓基质细胞（BMSCs）的研究为该领域开辟了新的途径。BMSCs 是一种具有强大增殖和分化潜能的干细胞，是成功建立基于干细胞的肝脏疾病治疗的有吸引力的工具。许多不同的基质细胞有助于 BMSCs 发挥治疗作用，因为 BMSCs 可以分化为功能性肝细胞，并可以产生一系列生长因子和细胞因子，能够抑制炎症反应、减少肝细胞凋亡、逆转肝纤维化和增强肝细胞功能。此外，已经表明 BMSCs 可以在某些微环境中增加癌细胞的凋亡率并抑制肿瘤转移。本综述重点介绍了 BMSCs 及其在肝再生和肝切除术后转移中的可能应用。
