Rigual Nestor R, Popat Saurin R, Jayaprakash Vijay, Jaggernauth Wainwright, Wong Michael
Roswell Park Cancer Institute, Department of Head & Neck Surgery & Plastic Surgery, Buffalo, NY-14263, USA.
Expert Rev Anticancer Ther. 2008 Mar;8(3):403-12. doi: 10.1586/14737140.8.3.403.
The incidence rate of malignant melanoma has shown a rapid worldwide rise in recent years. The staging and management of head and neck melanoma presents some unique challenges. Surgery remains the cornerstone of treatment, while sentinel node biopsy is the most accurate staging modality for regional disease. The complex regional anatomy and lymphovascular drainage of this region may account for the increased biologic aggressiveness and treatment challenges of this disease. Improved understanding of the radiobiology of melanoma has resulted in new adjuvant radiotherapy approaches, yielding improved control rates. The treatment outcomes of metastatic head and neck melanoma remain disappointing but important progress has been made in the understanding of melanoma biology.
近年来，恶性黑色素瘤的发病率在全球范围内呈快速上升趋势。头颈部黑色素瘤的分期和治疗面临一些独特的挑战。手术仍然是治疗的基石，而前哨淋巴结活检是区域疾病最准确的分期方式。该区域复杂的局部解剖结构和淋巴血管引流可能是导致这种疾病生物学侵袭性增加和治疗挑战的原因。对黑色素瘤放射生物学认识的提高带来了新的辅助放疗方法，提高了控制率。转移性头颈部黑色素瘤的治疗结果仍然令人失望，但在黑色素瘤生物学的认识方面已经取得了重要进展。
