Niiazbekova K Zh, Arzamova R A, Tleubergenov E T
Probl Tuberk. 1991(7):5-6.
The examination of 2150 children living in the epidemiologically unfavourable territories was carried out for 3 years (1988-1990) by a double Mantoux test with 2 TU PPD-L at a 6-month interval. By the end of the 3rd year primary contamination decreased by 2.8 times and local tuberculosis detection by 6.4 times. In the control group (1457 children) having the Mantoux test with 2 TU PPD-L once a year, primary contamination during the same time decreased by 1.2 times and tuberculosis detection by 1.4 times. Chemoprophylaxis was conducted in 3 groups of children: Group 1 was given only isoniazid for 3 months twice a year; group 2, isoniazid and ethambutol for 2 months once a year; and Group 3, isoniazid alone during 3 months. Chemoprophylaxis effectiveness in the epizootically unfavourable area was significantly higher when the two antibacterial drugs were used for 2 months once a year.
在3年（1988 - 1990年）期间，对生活在流行病学不利地区的2150名儿童进行了检查，采用2 TU PPD - L的双重结核菌素试验，间隔6个月进行一次。到第3年末，原发性感染减少了2.8倍，局部结核病检出率减少了6.4倍。在对照组（1457名儿童）中，每年进行一次2 TU PPD - L的结核菌素试验，同期原发性感染减少了1.2倍，结核病检出率减少了1.4倍。对3组儿童进行了化学预防：第1组每年两次给予异烟肼3个月；第2组每年一次给予异烟肼和乙胺丁醇2个月；第3组仅给予异烟肼3个月。在动物流行病不利地区，每年一次使用两种抗菌药物2个月时，化学预防效果显著更高。
