无味食物奖励。

Tasteless food reward.

作者信息

Andrews Zane B, Horvath Tamas L

机构信息

Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06519, USA.

出版信息

Neuron. 2008 Mar 27;57(6):806-8. doi: 10.1016/j.neuron.2008.03.004.

DOI:10.1016/j.neuron.2008.03.004

PMID:18367081

Abstract

Food palatability acts on the dopaminergic reward system to override homeostatic control; however, whether postingestive calorie load in the absence of taste affects this system remains unclear. In this issue of Neuron, de Araujo et al. show that mice lacking functional "sweet" taste receptors (trpm5-/-) develop a preference for sucrose by activating the mesolimbic dopamine-accumbal pathway, solely based on calorie load.

摘要

食物的适口性作用于多巴胺能奖赏系统以超越稳态控制；然而，在没有味觉的情况下，摄入后的卡路里负荷是否会影响该系统仍不清楚。在本期《神经元》杂志中，德·阿劳若等人表明，缺乏功能性“甜味”味觉受体的小鼠（trpm5基因敲除小鼠）仅基于卡路里负荷，通过激活中脑边缘多巴胺-伏隔核通路，对蔗糖产生了偏好。