Yuan Lei, Shen Fanghua, Lu Yuan, Liu Xishi, Guo Sun-Wei
Department of Gynecology, Shanghai Obstetrics and Gynecology Hospital, Shanghai Medical School, Fudan University, Shanghai, China.
Fertil Steril. 2009 Apr;91(4 Suppl):1303-6. doi: 10.1016/j.fertnstert.2008.01.070. Epub 2008 Mar 25.
Cyclooxegenase-2 expression was evaluated by immunohistochemistry in endometrioma tissue samples taken from 109 patients, of whom 53 had recurrence by 30 months after surgery and 56 did not. Cyclooxegenase-2 overexpression, along with previous medical treatment of endometriosis and the presence of adhesion, is predictive of recurrence of ovarian endometrioma within 30 months after surgery, with a resultant sensitivity of 72.5% and a specificity of 72.4%, suggesting that there are intrinsic and identifiable biomarkers that confer recurrence risk.
通过免疫组织化学方法对109例患者的子宫内膜异位囊肿组织样本进行环氧化酶-2表达评估，其中53例在术后30个月内复发，56例未复发。环氧化酶-2过表达，连同既往子宫内膜异位症的治疗情况和粘连的存在，可预测术后30个月内卵巢子宫内膜异位囊肿的复发，其敏感性为72.5%，特异性为72.4%，这表明存在赋予复发风险的内在且可识别的生物标志物。
