Minunni Maria, Scarano Simona, Mascini Marco
Department of Chemistry, University of Florence, Sesto Fiorentino (Firenze), Italy.
Trends Biotechnol. 2008 May;26(5):236-43. doi: 10.1016/j.tibtech.2008.02.005. Epub 2008 Mar 25.
Innovative bioanalytical approaches can be foreseen as interesting means for solving relevant emerging problems in anti-doping control. Sport authorities fear that the newer form of doping, so-called gene doping, based on a misuse of gene therapy, will be undetectable and thus much less preventable. The World Anti-Doping Agency has already asked scientists to assist in finding ways to prevent and detect this newest kind of doping. In this Opinion article we discuss the main aspects of gene doping, from the putative target analytes to suitable sampling strategies. Moreover, we discuss the potential application of affinity sensing in this field, which so far has been successfully applied to a variety of analytical problems, from clinical diagnostics to food and environmental analysis.
创新的生物分析方法有望成为解决反兴奋剂控制中相关新出现问题的有趣手段。体育当局担心，基于基因治疗滥用的新型兴奋剂，即所谓的基因兴奋剂，将无法被检测到，因此更难预防。世界反兴奋剂机构已经要求科学家协助寻找预防和检测这种最新兴奋剂的方法。在这篇观点文章中，我们讨论了基因兴奋剂的主要方面，从假定的目标分析物到合适的采样策略。此外，我们还讨论了亲和传感在该领域的潜在应用，到目前为止，亲和传感已成功应用于从临床诊断到食品和环境分析等各种分析问题。
