基因兴奋剂：从老鼠到人类

Gene doping: of mice and men.

作者信息

Azzazy Hassan M E, Mansour Mai M H, Christenson Robert H

机构信息

Department of Chemistry and YJ-Science & Technology Research Center, The American University in Cairo, New Cairo, Cairo, Egypt.

出版信息

Clin Biochem. 2009 Apr;42(6):435-41. doi: 10.1016/j.clinbiochem.2009.01.001. Epub 2009 Jan 20.

DOI:10.1016/j.clinbiochem.2009.01.001

PMID:19272337

Abstract

Gene doping is the newest threat to the spirit of fair play in sports. Its concept stemmed out from legitimate gene therapy trials, but anti-doping authorities fear that they now may be facing a form of doping that is virtually undetectable and extremely appealing to athletes. This paper presents studies that generated mouse models with outstanding physical performance, by manipulating genes such as insulin-like growth factor 1 (IGF-1) or phosphoenolpyruvate carboxykinase (PEPCK), which are likely to be targeted for gene doping. The potential transition from super mice to super athletes will also be discussed, in addition to possible strategies for detection of gene doping.

摘要

基因兴奋剂是体育界公平竞赛精神面临的最新威胁。其概念源于合法的基因治疗试验，但反兴奋剂机构担心，他们现在可能面临一种几乎无法检测且对运动员极具吸引力的兴奋剂形式。本文介绍了通过操纵胰岛素样生长因子1（IGF-1）或磷酸烯醇式丙酮酸羧激酶（PEPCK）等基因来培育具有出色体能的小鼠模型的研究，这些基因很可能成为基因兴奋剂的目标。除了基因兴奋剂的可能检测策略外，还将讨论从超级小鼠到超级运动员的潜在转变。