[Antibodies against Trypanosoma cruzi in intact mice and their oncoprotective effect].

Trypanosoma cruzi antibodies that are important in the anticancer effect of this species of Trypanosoma were first detected in 14% of the 374 examined intact mice. These background antibodies were polyclonal, i.e. they reacted with one or other of 9 genetically different T. cruzi clones and detected antigenic determinants in different structures of a Trypanosoma cell. Their spread in the population varied with animal batches; the titers were not greater than 1:40 and the level remained steady during a one-month observation. The growth of Ehrlich's adenomacarcinoma inoculated to these mice was inhibited by 1.5-2.5 times and, in some cases, terminated in total regression. The paper discusses the capacities of such antibodies in man and their inductor-commonness of the antigens of the normal intestinal microflora and the cells of the vertebrate with T. cruzi.