Guan Wang, Zhang Xiaoqin, Wang Xiao, Lu Shun, Yin Jun, Zhang Jinxin
Department of Cancer Prevention and Treatment, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Intensive Care Unit, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Front Pharmacol. 2019 Sep 25;10:1137. doi: 10.3389/fphar.2019.01137. eCollection 2019.
Cystic echinococcosis (CE), a devastating zoonotic condition caused by the tapeworm , remain a significant public health problem worldwide. However, after a negative correlation between solid tumor and CE has been incidentally discovered, accumulating evidence have suggested that this parasite may induce anticancer effect through activating host immune response and secreting molecules with anticancer potential, which may provide some new understanding for immunotherapy. This article will review the evidence supporting the anticancer effect of and its underlying mechanisms and discuss the possible implications in immunotherapy.
囊型包虫病（CE）是由绦虫引起的一种毁灭性人畜共患病，在全球范围内仍然是一个重大的公共卫生问题。然而，在偶然发现实体瘤与CE之间存在负相关后，越来越多的证据表明，这种寄生虫可能通过激活宿主免疫反应和分泌具有抗癌潜力的分子来诱导抗癌作用，这可能为免疫治疗提供一些新的认识。本文将综述支持其抗癌作用的证据及其潜在机制，并讨论其在免疫治疗中的可能意义。
