Tipoe George L, Liong Emily C, Leung Tung-Ming, Nanji Amin A
Department of Anatomy, The University of Hong Kong, Hong Kong, SAR China.
Methods Mol Biol. 2008;447:11-31. doi: 10.1007/978-1-59745-242-7_2.
The variety of animal models used in the study of alcoholic liver disease reflects the formidable task of developing a model that replicates the human disease. We show that oral feeding of fatty acids derived from fish oil and ethanol induces fatty liver, necrosis, inflammation, and fibrosis. Together with the study of oxidative and nitrosative stress markers, cytokines, proteasome function, and protein studies, this model has provided an inexpensive and technically simple method of establishing pathological alcoholic liver injury.
用于酒精性肝病研究的动物模型种类繁多，这反映出开发一种能复制人类疾病的模型是一项艰巨的任务。我们发现，经口给予鱼油衍生脂肪酸和乙醇会引发脂肪肝、坏死、炎症和纤维化。结合对氧化应激和亚硝化应激标志物、细胞因子、蛋白酶体功能以及蛋白质的研究，该模型提供了一种建立病理性酒精性肝损伤的廉价且技术简单的方法。
