Berkompas D C
Indiana University Medical Center, Indianapolis.
Indiana Med. 1991 Nov;84(11):788-91.
Oral anticoagulants are widely used in clinical practice. Hemorrhagic complications are the most frequent adverse reactions, but a rarer complication, coumadin skin necrosis, also can be seen. The recently described association with low levels of protein C and/or free protein S is of importance in the pathophysiology of coumadin skin necrosis. This article describes the case of a patient with a functional protein S deficiency who developed coumadin skin necrosis. The condition is described, and a discussion of theories regarding its pathophysiology is presented. Current treatment recommendations are listed.
口服抗凝剂在临床实践中广泛应用。出血并发症是最常见的不良反应，但一种较为罕见的并发症——华法林皮肤坏死也可见到。最近描述的与低水平蛋白C和/或游离蛋白S的关联在华法林皮肤坏死的病理生理学中具有重要意义。本文描述了一名患有功能性蛋白S缺乏症并发生华法林皮肤坏死的患者病例。对该病症进行了描述，并对其病理生理学的相关理论进行了讨论。列出了当前的治疗建议。
