Au Alexander F, Fosnot Joshua, Wu Liza C
Division of Plastic Surgery, University of Pennsylvania, Philadelphia, PA, USA.
Ann Plast Surg. 2012 Jul;69(1):109-10. doi: 10.1097/SAP.0b013e31821ee41c.
A case report of coumadin-induced skin necrosis (CISN) is presented, followed by a topic review of CISN, which reviews presentation, pathophysiology, differential diagnosis, prevention, and management of this disorder. The prevalence of CISN is low (0.01%-0.1% of patients receiving coumadin). However, of those affected, over 50% required some form of surgical debridement or reconstruction. Although skin necrosis secondary to coumadin therapy is rare, it is essential for plastic surgeons to be aware of this clinical entity in order to make the correct diagnosis and provide appropriate treatment.
本文报告了一例华法林诱导的皮肤坏死（CISN）病例，并对CISN进行了专题综述，内容涵盖了该疾病的临床表现、病理生理学、鉴别诊断、预防及治疗。CISN的发病率较低（接受华法林治疗的患者中占0.01%-0.1%）。然而，在受影响的患者中，超过50%需要某种形式的手术清创或重建。尽管华法林治疗继发的皮肤坏死很少见，但整形外科医生必须了解这一临床实体，以便做出正确诊断并提供适当治疗。
