Nigrostriatal pathway modulates striatum vulnerability to quinolinic acid.

作者信息

Buisson A, Pateau V, Plotkine M, Boulu R G

机构信息

Laboratoire de Pharmacologie, Faculté des Sciences Pharmaceutiques et Biologiques, Université René Descartes, Paris, France.

出版信息

Neurosci Lett. 1991 Oct 14;131(2):257-9. doi: 10.1016/0304-3940(91)90627-6.

This study evaluates the modulation of striatum vulnerability to quinolinic acid (QA) by the nitrostriatal projection. Unilateral lesioning of the substantia nigra with 6-hydroxydopamine markedly reduced the volume of striatal necrosis observed 3 days after local injection of quinolinic acid (150 nmol). This result is consistent with the concept that the nigrostriatal pathway potentiates the vulnerability of striatum to excitotoxic damage.