Wood John C, Claster Susan, Carson Susan, Menteer J D, Hofstra Thomas, Khanna Rachna, Coates Thomas
Division of Cardiology, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Br J Haematol. 2008 Jun;141(6):891-4. doi: 10.1111/j.1365-2141.2008.07135.x. Epub 2008 Mar 26.
Vitamin D25-OH and D1-25OH levels were compared with cardiac R2* (1/T2*), left ventricular ejection fraction (LVEF), age, ferritin and liver iron in 24 thalassaemia major patients. Vitamin D25-OH levels were reduced in 13/24 patients while vitamin D1-25OH levels were often elevated. Vitamin D25-OH levels decreased with age (r(2) = 0.48) and with liver iron (r(2) = 0.20). Cardiac R2* was inversely related with the ratio of D25-OH to D1-25OH levels (r(2) = 0.42). LVEF was also proportional to the D25-OH/D1-25OH ratio (r(2) = 0.49). Vitamin D deficiency may be associated with cardiac iron uptake and ventricular dysfunction in thalassaemia major patients.
对24例重型地中海贫血患者的维生素D 25-OH和D1-25OH水平与心脏R2*(1/T2*)、左心室射血分数(LVEF)、年龄、铁蛋白及肝脏铁含量进行了比较。13/24例患者的维生素D 25-OH水平降低,而维生素D1-25OH水平常升高。维生素D 25-OH水平随年龄(r(2)=0.48)和肝脏铁含量(r(2)=0.20)降低。心脏R2*与D25-OH和D1-25OH水平的比值呈负相关(r(2)=0.42)。LVEF也与D25-OH/D1-25OH比值成正比(r(2)=0.49)。维生素D缺乏可能与重型地中海贫血患者的心脏铁摄取和心室功能障碍有关。