Hooper Andrea T, Butler Jason, Petit Isabelle, Rafii Shahin
Howard Hughes Medical Institute, Weill Cornell Medical College, New York, NY 10021, USA.
Cell Stem Cell. 2007 Aug 16;1(2):127-9. doi: 10.1016/j.stem.2007.07.012.
In this issue of Cell Stem Cell, Kiel et al. (2007) demonstrate that N-cadherin is not expressed on repopulating hematopoietic stem cells (HSCs) and that reduction of osteoblasts does not affect HSC frequency, suggesting that other molecular pathways may also modulate the interaction of HSCs with their niches.
在本期《细胞·干细胞》杂志中,基尔等人(2007年)证明,N-钙黏蛋白在能够进行自我更新的造血干细胞(HSCs)上并不表达,并且成骨细胞数量的减少并不影响造血干细胞的频率,这表明其他分子途径也可能调节造血干细胞与其微环境之间的相互作用。