Center for Clinical Molecular Medicine, Chongqing Medical University, Chongqing 400014, China.
Crit Rev Oncol Hematol. 2013 Jan;85(1):1-8. doi: 10.1016/j.critrevonc.2012.05.004. Epub 2012 Jun 27.
Hematopoietic stem cells (HSCs) are characterized with long-term self-renewal and multi-lineage differentiation. HSCs preferentially reside in osteoblastic niche that is hierarchically organized so as to exactly regulate HSCs properties and maintain organism hematopoietic homeostasis. Hematopoietic stem cell-mesenchymal stem cell pairings share stem cell niches in adult bone marrow under immune-humoral-neural regulation. Here, we review the hierarchical HSC osteoblastic niche in terms of its localization, composition, function, and multi-layer regulation systems.
造血干细胞（HSCs）的特征是长期自我更新和多谱系分化。HSCs 优先位于成骨细胞龛位，该龛位呈层次化组织，以便精确调节 HSCs 的特性并维持机体造血稳态。在免疫-体液-神经调节下，造血干细胞-间充质干细胞对在成人骨髓中共享干细胞龛位。在此，我们从定位、组成、功能和多层次调控系统等方面综述了 HSC 成骨细胞龛位的层级结构。
