LIS1与神经上皮细胞中的纺锤体定向

LIS1 and spindle orientation in neuroepithelial cells.

作者信息

Schwamborn Jens C, Knoblich Juergen A

机构信息

Institute of Molecular Biotechnology of Austrian Academy of Sciences, Dr. Bohr-Gasse 3, 1030 Vienna, Austria.

出版信息

Cell Stem Cell. 2008 Mar 6;2(3):193-4. doi: 10.1016/j.stem.2008.02.010.

DOI:10.1016/j.stem.2008.02.010

PMID:18371441

Abstract

Asymmetric stem cell division is thought to require precise orientation of the mitotic spindle. However, a recent study in Cell (Yingling et al., 2008) analyzes the role of LIS1 in the developing mouse brain and shows that spindle orientation is more important during early, symmetric progenitor cell divisions than for later asymmetric divisions.

摘要

不对称干细胞分裂被认为需要有丝分裂纺锤体的精确取向。然而，《细胞》杂志最近的一项研究（英林等人，2008年）分析了LIS1在发育中的小鼠大脑中的作用，并表明纺锤体取向在早期对称祖细胞分裂过程中比在后期不对称分裂过程中更为重要。