Walker Mike, Hadgraft Jonathan, Lane Majella E
ConvaTec Wound Therapeutics, Global Development Centre, 1st Avenue, Deeside Industrial Park, Deeside, Flintshire CH5 2NU, UK.
Int J Pharm. 2008 Jun 5;357(1-2):1-5. doi: 10.1016/j.ijpharm.2008.01.063. Epub 2008 Mar 10.
Excessive wound exudate in chronic wounds can cause skin maceration to occur around a wound, which may delay healing and lead to other complications. In order to assess possible treatment options with topical therapy there is a need to characterize the permeability of wound and peri-ulcer tissue. Previously we have reported the permeability of a range of chemicals with differing physicochemical properties in human ulcerated and peri-ulcer ischaemic tissue. The findings suggested that wound tissue and peri-ulcer tissue were not representative of normally functioning skin barriers. In the present work we have investigated the permeability of tritiated water in peri-ulcer and whole skin human tissue obtained from clinically diagnosed diabetic ischaemic patients. Permeability data for peri-ulcer tissue was generally higher and more variable than for normal tissue. Histological examination confirmed the breakdown of the skin tissue in the peri-ulcer area and also in the normal skin tissue samples taken from diabetic ischaemic patients. The impaired skin barrier function both in the peri-ulcer and normal tissue may offer opportunities for dermal and transdermal therapies for management of diabetes-related complications.
慢性伤口中过多的伤口渗出液会导致伤口周围皮肤浸渍，这可能会延迟愈合并引发其他并发症。为了评估局部治疗的可能方案，有必要对伤口及溃疡周围组织的通透性进行表征。此前我们报道了一系列具有不同物理化学性质的化学物质在人类溃疡及溃疡周围缺血组织中的通透性。研究结果表明，伤口组织和溃疡周围组织并不代表正常功能的皮肤屏障。在本研究中，我们研究了氚标记水在从临床诊断为糖尿病缺血患者获取的溃疡周围及全层皮肤组织中的通透性。溃疡周围组织的通透性数据通常比正常组织更高且更具变异性。组织学检查证实了溃疡周围区域以及从糖尿病缺血患者获取的正常皮肤组织样本中皮肤组织的破坏。溃疡周围和正常组织中受损的皮肤屏障功能可能为糖尿病相关并发症的皮肤和透皮治疗提供机会。
