Maicas Vicente Tormo, Rochina Iván Julián
Departament d'Infermeria, Universitat de València Estudi General.
Rev Enferm. 2008 Apr;31(4):26-32.
The authors present a clinical and documented follow up on the peri-lesion skin in 44 venal blood vessel ulcers which were treated by a hyper-oxygenized fatty acid emulsion. All the elderly in this study belonged to the Number 3 Health Department of the Valencia Sanitary Council. This study's protocol and its data collection register received a favourable report from the Committee on Research Ethics at the "La Plana" Hospital. With a total percentage of 60 in essential linoleic fatty acid, CORPITOLINOL 60, is the emulsion which has the greatest quantity of this element so necessary for human skin. In effect, this is the essential fatty acid which has the greatest presence in human skin, besides being a vital element for skin hydration and its viability to form part of a fundamental structure: intercellular layers in the corneum layer of the epidermis. On the other hand, in the hyper-oxygenation process, this product helps the skin to obtain molecules very similar to prostaglandins land 2 which favour tissue perfusion. The main objective of this study has been to evaluate, after the application of this emulsion over a four week time period, the reduction of erythema and peri-lesion hyperkeratosis in venal blood vessel ulcers. But at the same time, as a secondary objective, this study evaluated peri-lesion skin based on other criteria such as pruritus, lesions due to scratching, or edema; this study verified whether treatment of peri-lesion skin influences the cicatrisation of wounds, as well as treatment acceptance by health professionals and patients. Incidences of erythemas and hyperkeratosis totally disappeared in 40% and 50% of those cases, respectively; in those lesions where these symptoms continued after four weeks of treatment there was a significant reduction in the degree of both erythemas and hyperkeratosis, 25% in each case. These researchers consider that good treatment of peri-lesion skin combined with a standard cure protocol, using "Urgotul" as the primary dressing, helped to achieve an overall 45% cicatrisation rate plus an 80% total cicatrized surface area. To these results, these researchers noted fine tolerance for the treatment employed and a very high acceptability level for this treatment by health professionals. To sum up, the analysis of the results of this clinical study prove the efficiency of "Corpitol Emulsion"; in addition, its fine tolerance and its high acceptability level make this product adaptable to the treatment of venal blood vessel ulcers in lower limbs when these ulcers are caused by varicose veins or a have a mixed cause with varicose veins as a predominant factor.
作者介绍了对44例经高氧脂肪酸乳剂治疗的静脉血管溃疡周围皮肤的临床及记录随访情况。本研究中的所有老年人均来自瓦伦西亚卫生委员会第3卫生部门。本研究方案及其数据收集记录获得了“拉普拉纳”医院研究伦理委员会的有利报告。CORPITOLINOL 60这种乳剂的必需亚油酸总含量为60%，是含这种对人体皮肤极为必要元素最多的乳剂。实际上，这是在人体皮肤中含量最高的必需脂肪酸，同时也是皮肤水合作用及其形成表皮角质层细胞间层这一基本结构的活力的关键要素。另一方面，在高氧过程中，该产品有助于皮肤获取与前列腺素1和2非常相似的分子，从而促进组织灌注。本研究的主要目的是评估在四周时间内应用这种乳剂后，静脉血管溃疡红斑和溃疡周围皮肤角化过度的减轻情况。但同时，作为次要目的，本研究基于其他标准评估溃疡周围皮肤，如瘙痒、搔抓引起的损伤或水肿；本研究验证了溃疡周围皮肤的治疗是否会影响伤口愈合，以及医护人员和患者对治疗的接受程度。红斑和角化过度的发生率分别在40%和50%的病例中完全消失；在治疗四周后这些症状仍持续的病变中，红斑和角化过度的程度均有显著减轻，各为25%。这些研究人员认为，对溃疡周围皮肤进行良好治疗并结合标准治疗方案，以“优拓”作为主要敷料，有助于实现总体45%的愈合率以及80%的总愈合表面积。基于这些结果，这些研究人员指出该治疗方法耐受性良好，医护人员对该治疗的接受度非常高。总之，对这项临床研究结果的分析证明了“Corpitol乳剂”的有效性；此外，其良好的耐受性和高接受度使该产品适用于治疗下肢静脉血管溃疡，这些溃疡由静脉曲张引起或主要由静脉曲张混合因素导致。
