Carboni Giovanni L, Fahrner Rene, Gazdhar Amiq, Printzen Gert, Schmid Ralph Alexander, Hoksch Beatrix
Division of General Thoracic Surgery, University Hospital Berne, 3010 Berne, Switzerland.
Eur J Cardiothorac Surg. 2008 May;33(5):777-80. doi: 10.1016/j.ejcts.2008.02.013.
The objective of this prospective study was to compare the clinical value of procalcitonin (PCT) and C-reactive protein (CrP) plasma concentrations in their postoperative course after decortication.
Twenty-two patients requiring surgery for pleural empyema were chosen for this prospective study. Routine blood samples including CrP and PCT plasma concentrations were taken before the operation and on the 1st, 2nd, 3rd, and 7th postoperative day.
Due to infection PCT and CrP were elevated preoperatively. In the postoperative course both PCT and CrP reached peak-levels on day 2 with values up to 43.55 ng/ml and 384.00 mg/l, respectively. In PCT the rise was followed by a clear decrease in 20 (90.9 %) patients until day 7. In contrast the CrP levels decreased slowly and only seven (54.5%) patients had values of 100 mg/l or below on day 7. PCT showed a better correlation with the clinic in case of septic course than CrP does.
PCT reflects postoperative clinical course more accurately than CrP. Therefore, PCT is a more appropriate laboratory parameter to monitor patients after surgery for pleural empyema.
本前瞻性研究的目的是比较降钙素原（PCT）和C反应蛋白（CrP）血浆浓度在胸膜纤维板剥脱术后病程中的临床价值。
本前瞻性研究选取了22例因胸腔积液需要手术治疗的患者。在手术前以及术后第1、2、3和7天采集包括CrP和PCT血浆浓度在内的常规血样。
由于感染，术前PCT和CrP升高。在术后病程中，PCT和CrP均在第2天达到峰值，分别高达43.55 ng/ml和384.00 mg/l。在PCT方面，20例（90.9%）患者至第7天出现明显下降。相比之下，CrP水平下降缓慢，至第7天只有7例（54.5%）患者的值低于100 mg/l。在脓毒症病程中，PCT与临床情况的相关性比CrP更好。
PCT比CrP更准确地反映术后临床病程。因此，PCT是监测胸腔积液手术后患者更合适的实验室指标。
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