Pössel Patrick, Lo Hanna, Fritz Anne, Seemann Simone
University of Tübingen, Germany.
Biol Psychol. 2008 May;78(2):173-8. doi: 10.1016/j.biopsycho.2008.02.004. Epub 2008 Feb 21.
The objective of this study is to test Davidson's, and Heller and Nitschke's models stating cortical activity in adolescents to be a marker for increased risk for depression.
Alpha activity was measured in 80 adolescents from medial-frontal (F3/4), lateral-frontal (F7/8), and medial-parietal (P3/4) electrodes, as well as self-reported depression and anxiety twice within 12 months. Step-wise hierarchical regression analyses with anxiety as covariate were calculated with alpha asymmetry as predicting variable and depression as target variable and vice versa.
Independent of whether anxiety was used as covariate or not, frontal and parietal alpha asymmetry predict depression, but depression did not predict alpha activity.
The results partially support both models and conclusions drawn by studies with remitted depressed subjects. However, it remains unclear if anxious arousal has a partial influence on the predictive association between alpha activity and depression.
本研究的目的是检验戴维森以及赫勒和尼奇克的模型，这些模型表明青少年的皮质活动是抑郁症风险增加的一个标志。
对80名青少年的额中（F3/4）、额侧（F7/8）和顶中（P3/4）电极处的阿尔法活动进行测量，并在12个月内两次进行自我报告的抑郁和焦虑情况调查。以焦虑为协变量，进行逐步分层回归分析，以阿尔法不对称性作为预测变量，抑郁作为目标变量，反之亦然。
无论是否将焦虑用作协变量，额叶和顶叶的阿尔法不对称性都能预测抑郁，但抑郁不能预测阿尔法活动。
研究结果部分支持了这两个模型以及对缓解期抑郁症患者进行研究得出的结论。然而，尚不清楚焦虑唤起是否对阿尔法活动与抑郁之间的预测关联有部分影响。
