Ablin Jacob, Neumann Lily, Buskila Dan
Department of Rheumatology, Institute of Rheumatology, Tel-Aviv Sourasky Medical Center and Sackler Faculty of Medicine, 6 Weizman St., Tel-Aviv University, Tel-Aviv 64239, Israel.
Joint Bone Spine. 2008 May;75(3):273-9. doi: 10.1016/j.jbspin.2007.09.010. Epub 2008 Mar 28.
Fibromyalgia, a syndrome characterized by widespread pain and diffuse tenderness, is considered a multifactorial disorder. Central nervous system sensitization is a major pathophysiological aspect of fibromyalgia, while various external stimuli such as infection, trauma and stress may contribute to development of the syndrome. In addition, current evidence points towards the existence of a genetic basis for fibromyalgia and information has been accumulated regarding the role of a number of candidate genes in fibromyalgia pathogenesis. In the present review, we have summarized the clinical manifestations of fibromyalgia, as well as the necessary laboratory workup; subsequently we have attempted to cover various aspects of pathogenesis with special emphasis on the genetic aspects currently uncovered.
纤维肌痛是一种以广泛疼痛和弥漫性压痛为特征的综合征，被认为是一种多因素疾病。中枢神经系统致敏是纤维肌痛的主要病理生理方面，而各种外部刺激，如感染、创伤和压力，可能导致该综合征的发生。此外，目前的证据表明纤维肌痛存在遗传基础，并且已经积累了关于许多候选基因在纤维肌痛发病机制中作用的信息。在本综述中，我们总结了纤维肌痛的临床表现以及必要的实验室检查；随后，我们试图涵盖发病机制的各个方面，特别强调目前已发现的遗传方面。
