Hudson Michael J, Beyer Wolfgang, Böhm Reinhard, Fasanella Antonio, Garofolo Giuliano, Golinski Robert, Goossens Pierre L, Hahn Ulrike, Hallis Bassam, King Annemarie, Mock Michèle, Montecucco Cesare, Ozin Amanda, Tonello Fiorella, Kaufmann Stefan H E
Health Protection Agency, Porton Down, Salisbury, UK.
Int J Med Microbiol. 2008 Jul;298(5-6):345-64. doi: 10.1016/j.ijmm.2007.09.007. Epub 2008 Mar 28.
Anthrax Euronet, a Coordination Action of the EU 6th Framework Programme, was designed to strengthen networking activities between anthrax research groups in Europe and to harmonise protocols for testing anthrax vaccines and therapeutics. Inevitably, the project also addressed aspects of the current political issues of biosecurity and dual-use research, i.e. research into agents of important diseases of man, livestock or agriculture that could be used as agents of bioterrorism. This review provides a comprehensive overview of the biology of Bacillus anthracis, of the pathogenesis, epidemiology and diagnosis of anthrax, as well as vaccine and therapeutic intervention strategies. The proposed requirement for a code of conduct for working with dual-use agents such as the anthrax bacillus is also discussed.
“炭疽欧洲网络”是欧盟第六框架计划的一项协调行动，旨在加强欧洲炭疽研究小组之间的网络活动，并统一炭疽疫苗和治疗方法的测试方案。不可避免地，该项目还涉及了当前生物安全和两用研究的政治问题，即对人类、牲畜或农业重要疾病病原体的研究，这些病原体可能被用作生物恐怖主义制剂。本综述全面概述了炭疽芽孢杆菌的生物学特性、炭疽的发病机制、流行病学和诊断方法，以及疫苗和治疗干预策略。还讨论了针对诸如炭疽杆菌等两用制剂制定行为准则的提议要求。
