Parikh Alexander A, Johnson J Chad, Merchant Nipun B
Vanderbilt University School of Medicine, 597 PRB, 2220 Pierce Avenue, Nashville, TN 37232, USA.
Surg Oncol Clin N Am. 2008 Apr;17(2):257-77, vii. doi: 10.1016/j.soc.2007.12.001.
Sequencing of the human genome and the acquisition of genomic data combined with advances in genomic and proteomic technologies have fueled a revolution in understanding disease. The combination of genomics and proteomics has provided a unique opportunity to diagnose, classify, and detect malignant disease, to better understand and define the behavior of specific tumors, and to provide direct and targeted therapy. Nevertheless, challenges remain, including integration and standardization of techniques and validation against accepted clinical and pathologic parameters. This article provides a summary of technologies, potential clinical applications, and challenges.
人类基因组测序以及基因组数据的获取，再加上基因组学和蛋白质组学技术的进步，推动了疾病认识领域的一场革命。基因组学和蛋白质组学的结合为诊断、分类和检测恶性疾病、更好地理解和界定特定肿瘤的行为以及提供直接和靶向治疗提供了独特的机会。然而，挑战依然存在，包括技术的整合与标准化以及对照公认的临床和病理参数进行验证。本文对相关技术、潜在的临床应用及挑战进行了总结。
