Kim Catherine, Cheng Yiling J, Beckles Gloria L
Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Diabetes Care. 2008 Jul;31(7):1386-8. doi: 10.2337/dc07-2362. Epub 2008 Mar 28.
We compared inflammatory markers among women with a history of gestational diabetes mellitus (hGDM), women with diagnosed diabetes, and unaffected women in a population-based sample.
We conducted cross-sectional analyses of 6,346 nonpregnant women in the Third National Health and Nutrition Examination Survey (1988-1994). Women were classified as having hGDM (n = 87), diagnosed diabetes (n = 244), or neither condition (n = 6,015). Inflammatory markers included ferritin, leukocyte count, and C-reactive protein levels.
After adjustment, women with diagnosed diabetes had the most marked differences in inflammatory markers compared with unaffected women. Differences between unaffected women and women with hGDM were minimal.
Women with diagnosed diabetes have less favorable inflammation profiles than unaffected women and greater ferritin levels than women with hGDM. After adjustment, women with hGDM who have not developed diagnosed diabetes have inflammation profiles similar to those of unaffected women.
在一个基于人群的样本中，我们比较了有妊娠期糖尿病病史（hGDM）的女性、已确诊糖尿病的女性和未受影响女性之间的炎症标志物。
我们对第三次全国健康和营养检查调查（1988 - 1994年）中的6346名非妊娠女性进行了横断面分析。女性被分类为患有hGDM（n = 87）、已确诊糖尿病（n = 244）或两者都无（n = 6015）。炎症标志物包括铁蛋白、白细胞计数和C反应蛋白水平。
调整后，与未受影响的女性相比，已确诊糖尿病的女性在炎症标志物方面存在最显著的差异。未受影响的女性与患有hGDM的女性之间的差异最小。
已确诊糖尿病的女性与未受影响的女性相比，炎症指标更不理想，且铁蛋白水平高于患有hGDM的女性。调整后，未发展为已确诊糖尿病的患有hGDM的女性的炎症指标与未受影响的女性相似。
