Takahashi N, Tamaki N, Ohtani H, Shindo M, Kawamoto M, Yonekura Y, Ono S, Nohara R, Kambara H, Kawai C
Department of Radiology and Nuclear Medicine, Kyoto University Faculty of Medicine.
Kaku Igaku. 1991 Sep;28(9):1021-7.
To evaluate clinical value of 99mTc-hexakis 2-methoxy-2-isobutyl isonitrile (MIBI) imaging for assessing coronary artery disease (CAD), 99mTc-MIBI SPECT imaging at post-exercise and at rest was compared with 201Tl SPECT imaging at post-exercise and 3 hours redistribution in 27 patients suspected with CAD. The sensitivities for detecting CAD patients were 94% (17/18) by both studies. The specificities were 71% (5/7) by 99mTc-MIBI and 57% (4/7) by 201Tl (p = NS). The sensitivities for detecting stenosed coronary arteries (greater than or equal to 75% stenosis) were also similar between 99mTc-MIBI (78%) and 201Tl (74%) (p = NS). The similar specificity values were obtained by 99mTc-MIBI (84%) and by 201Tl (82%) (p = NS). The patterns of abnormality (normal, ischemia and scar) were similar between 99mTc-MIBI and 201Tl images in 22 of the 25 cases (88%) and 117 of the 125 segments (94%). However, these patterns were occasionally different particularly in patients who received PTCA or CABG. Thus, 99mTc-MIBI SPECT imaging seems to be as accurate as 201Tl SPECT imaging for the detecting and evaluating CAD.
为评估99m锝-六甲氧基-2-异丁基异腈（MIBI）显像在评估冠状动脉疾病（CAD）中的临床价值，对27例疑似CAD患者运动后及静息状态下的99mTc-MIBI单光子发射计算机断层显像（SPECT）与运动后及3小时再分布状态下的201铊（201Tl）SPECT显像进行了比较。两项研究检测CAD患者的敏感性均为94%（17/18）。99mTc-MIBI的特异性为71%（5/7），201Tl的特异性为57%（4/7）（p=无显著性差异）。99mTc-MIBI（78%）和201Tl（74%）检测狭窄冠状动脉（狭窄程度大于或等于75%）的敏感性也相似（p=无显著性差异）。99mTc-MIBI（84%）和201Tl（82%）获得的特异性值相似（p=无显著性差异）。25例中的22例（88%）以及125个节段中的117个（94%），99mTc-MIBI和201Tl图像的异常模式（正常、缺血和瘢痕）相似。然而，这些模式偶尔会有所不同，尤其是在接受经皮冠状动脉腔内血管成形术（PTCA）或冠状动脉旁路移植术（CABG）的患者中。因此，99mTc-MIBI SPECT显像在检测和评估CAD方面似乎与201Tl SPECT显像一样准确。
