For improving quality and efficiency of health delivery under the wellknown burdens, the health service paradigm has to change from organization-centered over process-controlled to personal health. Established in connection to the already existing International Center for Telemedicine, the eHealth Competence Center in Regensburg has been dedicated to advance research, development, education and administration of comprehensive eHealth. In cooperation with internal and external partners, the Personal Health paradigm comprising of health telematics, telemedicine, biomedical engineering, bioinformatics and genomics is pushed ahead. The paper introduces the underlying paradigms, requirements, architectural framework and development processes for comprehensive service-oriented Personal Health interoperability chains.