Al-Ahmadi Khaled, Ahmed Najma
Trauma Program and Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
Can J Surg. 2008 Apr;51(2):118-24.
Pancreatic injury following trauma is unusual, and there are few data regarding outcomes, particularly with respect to endocrine and exocrine function. The purpose of this study was to review our institutional experience in regard to this relatively infrequent injury and to determine the incidence of trauma-induced endocrine and exocrine pancreatic dysfunction as indicated by patient self-report.
After receiving institutional research ethics approval, we identified all patients with pancreatic injuries in our trauma registry database over a 5-year period. The diagnostic, operative information, hospital course and complication rates were abstracted from medical records. Patients who could be contacted completed a telephone-administered questionnaire to assess pancreatic function.
We identified 25 patients who had suffered a pancreatic injury. Of these, 16 patients suffered blunt injury, and 9 suffered penetrating injury. Of the 25 patients, 13 underwent pancreatic surgery, and 6 required distal pancreatectomy. Early pancreas-specific complications occurred in 7 of 22 surviving patients (31.8%). Of the 25 patients identified, 6 could not be contacted for follow-up information. Of 19 patients contacted, 4 reported endocrine dysfunction. One of these was insulin-dependent before injury. No patient in this series reported exocrine dysfunction. The overall mortality rate in our series was 12%.
Pancreatic injuries comprised about 1% of injuries captured by our trauma registry. Outcomes were similar in patients who suffered blunt or penetrating trauma. Of these patients, 52% underwent pancreatic surgery; 16% of patients in this small series reported endocrine deficiency posttrauma.
创伤后胰腺损伤并不常见,关于其预后的数据较少,尤其是在内分泌和外分泌功能方面。本研究的目的是回顾我们机构对这种相对罕见损伤的诊治经验,并通过患者自我报告确定创伤性胰腺内分泌和外分泌功能障碍的发生率。
获得机构研究伦理批准后,我们在创伤登记数据库中识别了5年内所有胰腺损伤患者。从病历中提取诊断、手术信息、住院过程和并发症发生率。能够联系到的患者完成了一份电话调查问卷以评估胰腺功能。
我们识别出25例胰腺损伤患者。其中,16例为钝性损伤,9例为穿透性损伤。25例患者中,13例接受了胰腺手术,6例需要行胰体尾切除术。22例存活患者中有7例(31.8%)发生了早期胰腺特异性并发症。在识别出的25例患者中,6例无法取得随访信息。在联系到的19例患者中,4例报告有内分泌功能障碍。其中1例在受伤前依赖胰岛素治疗。本系列中无患者报告有外分泌功能障碍。本系列的总死亡率为12%。
胰腺损伤约占我们创伤登记所记录损伤的1%。钝性或穿透性创伤患者的预后相似。这些患者中,52%接受了胰腺手术;在这个小系列中,16%的患者创伤后报告有内分泌功能不足。