在多发性硬化症早期，膜结合型白细胞介素-15在CD14单核细胞上增加。
Membrane bound IL-15 is increased on CD14 monocytes in early stages of MS.
作者信息
Vaknin-Dembinsky Adi, Brass Steven D, Gandhi Roopali, Weiner Howard L
机构信息
Center for Neurological Diseases, Brigham and Women's Hospital, Harvard Medical, School, Boston Massachusetts 02115, United States.
出版信息
J Neuroimmunol. 2008 Mar;195(1-2):135-9. doi: 10.1016/j.jneuroim.2008.01.016. Epub 2008 Apr 1.
IL-15 is a pro-inflammatory cytokine whose three-dimensional structure is similar to that of IL-2. IL-2 and IL-15 have similar as well as distinct biological functions. An active form of IL-15 that is membrane bound has also been described. Furthermore, IL-15 is known to play a role in autoimmune diseases. We thus investigated the expression of membrane bound IL-15 on monocytes (CD14+ cells) and studied its effect on T cell activation in MS patients. We found that unstimulated CD14+ cells from relapsing remitting MS patients had increased membrane bound IL-15. Those with high surface levels of IL-15 on monocytes were in the early stages of the disease. In addition, we found that T cells of MS patients had enhanced responsiveness to IL-15 and there was increased expression of IL-15 receptor on CD4+ T cells. Thus, IL-15 may be an important cytokine that drives Th1 responses early in the course of the disease and could serve as a target for immunotherapy and as an early marker in the immunologic staging of MS.
白细胞介素-15（IL-15）是一种促炎细胞因子，其三维结构与白细胞介素-2（IL-2）相似。IL-2和IL-15具有相似但又不同的生物学功能。还描述了一种膜结合的活性形式的IL-15。此外，已知IL-15在自身免疫性疾病中起作用。因此，我们研究了膜结合IL-15在单核细胞（CD14+细胞）上的表达，并研究了其对多发性硬化症（MS）患者T细胞活化的影响。我们发现，复发缓解型MS患者未受刺激的CD14+细胞上膜结合IL-15增加。单核细胞表面IL-15水平高的患者处于疾病早期。此外，我们发现MS患者的T细胞对IL-15的反应性增强，且CD4+T细胞上IL-15受体的表达增加。因此，IL-15可能是一种重要的细胞因子，在疾病早期驱动Th1反应，可作为免疫治疗的靶点以及MS免疫分期的早期标志物。
Zotero 插件