Bettelli Estelle, Oukka Mohamed, Kuchroo Vijay K
Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Nat Immunol. 2007 Apr;8(4):345-50. doi: 10.1038/ni0407-345.
CD4(+) effector T cells have been categorized into two subsets: T helper type 1 (T(H)1) and T(H)2. Another subset of T cells that produce interleukin 17 (IL-17; 'T(H)-17 cells') has been identified that is highly proinflammatory and induces severe autoimmunity. Whereas IL-23 serves to expand previously differentiated T(H)-17 cell populations, IL-6 and transforming growth factor-beta (TGF-beta) induce the differentiation of T(H)-17 cells from naive precursors. These data suggest a dichotomy between CD4(+) regulatory T cells positive for the transcription factor Foxp3 and T(H)-17 cells: TGF-beta induces Foxp3 and generates induced regulatory T cells, whereas IL-6 inhibits TGF-beta-driven Foxp3 expression and together with TGF-beta induces T(H)-17 cells. Emerging data regarding T(H)-17 cells suggest a very important function for this T cell subset in immunity and disease.
CD4(+)效应T细胞已被分为两个亚群：1型辅助性T细胞（T(H)1）和T(H)2。另一个产生白细胞介素17（IL-17；“T(H)-17细胞”）的T细胞亚群已被鉴定出来，其具有高度促炎作用并可诱导严重自身免疫。虽然IL-23用于扩增先前分化的T(H)-17细胞群体，但IL-6和转化生长因子-β（TGF-β）可诱导幼稚前体分化为T(H)-17细胞。这些数据表明转录因子Foxp3阳性的CD4(+)调节性T细胞与T(H)-17细胞之间存在二分法：TGF-β诱导Foxp3并产生诱导性调节性T细胞，而IL-6抑制TGF-β驱动的Foxp3表达，并与TGF-β一起诱导T(H)-17细胞。关于T(H)-17细胞的新数据表明该T细胞亚群在免疫和疾病中具有非常重要的功能。
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