β-环糊精衍生物对炭疽致死毒素的体内疗效
In vivo efficacy of beta-cyclodextrin derivatives against anthrax lethal toxin.
作者信息
Moayeri Mahtab, Robinson Tanisha M, Leppla Stephen H, Karginov Vladimir A
机构信息
Bacterial Toxins and Therapeutics Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
出版信息
Antimicrob Agents Chemother. 2008 Jun;52(6):2239-41. doi: 10.1128/AAC.00009-08. Epub 2008 Mar 31.
Abstract
We evaluated the in vivo efficacy of three beta-cyclodextrin derivatives that block the anthrax protective antigen pore. These compounds were at least 15-fold more potent than previously described beta-cyclodextrins in protecting against anthrax lethal toxin in a rat model. One of the drugs was shown to protect mice from bacterial infection.
摘要
我们评估了三种可阻断炭疽保护性抗原孔的β-环糊精衍生物的体内疗效。在大鼠模型中，这些化合物在抵御炭疽致死毒素方面的效力比先前描述的β-环糊精至少高15倍。其中一种药物被证明可保护小鼠免受细菌感染。
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