Antilipidemic drugs. Part 6: LF 178 in man. A preliminary note on a multicenter investigation bearing on 393 subjects with pure or mixed forms of hyperlipidemia.

A total of 393 patients affected by different foms of hyperlipoproteinemia have been treated for up to 12 months or more with a daily dose of 200-400 mg of isopropyl-4'-(p-chlorobenzoyl)-2-phenoxy-2-methyl]-propionate (LF 178; procetofene; Lipanthyl). In pure hypercholesterolemia (IIa) the mean depression of cholesterol exceeded 26% and the drug induced degree of normalization was 85%. In mixed hypercholesterolemia (IIa) cholesterol was depressed by 23% and triglycerides by approximately 40%. In major affections of hypercholesterolemia (cholesterol > 3.5 gll) the mean induced depression exceeded 30%. Pure hypertriglyceridemia (IV) was strongly affected by the drug LF 178 induced a mean depression of triglycerides exceeding 60% after 6 months of treatment. In all cases the antilipidemic effect was fast and well sustained...