简单生物碱的一锅法合成：2,3-聚亚甲基-4(3H)-喹唑啉酮、路脱宁A、色胺酮和吴茱萸次碱。
One-pot synthesis of simple alkaloids: 2,3-polymethylene-4(3H)-quinazolinones, luotonin A, tryptanthrin, and rutaecarpine.
作者信息
Jahng Katherine Chae, Kim Seung Ill, Kim Dong Hyeon, Seo Chang Seob, Son Jong-Keun, Lee Seung Ho, Lee Eung Seok, Jahng Yurngdong
机构信息
College of Pharmacy, Yeungnam University, Gyeongsan, Korea.
出版信息
Chem Pharm Bull (Tokyo). 2008 Apr;56(4):607-9. doi: 10.1248/cpb.56.607.
PMID:18379119
Abstract
One-pot synthesis of various 2,3-polymethylene-4(3H)-quinazolinones from anthranilic acid, corresponding lactam and SOCl(2) is described, which can be applicable to the synthesis of simple 4(3H)-quinazolinone-derived alkaloids, such as luotonin A, tryptanthrin, and rutaecarpine.
摘要
描述了一种由邻氨基苯甲酸、相应的内酰胺和氯化亚砜一锅法合成各种2,3-聚亚甲基-4(3H)-喹唑啉酮的方法，该方法可应用于简单的4(3H)-喹唑啉酮衍生生物碱的合成，如路脱宁A、靛玉红和吴茱萸次碱。
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