Khalil M A, Habib N S
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Egypt.
Farmaco Sci. 1987 Dec;42(12):973-8.
Three series of quinazolinone derivatives were synthesised namely: 3-[4-(2-substituted amino-1,3,4-thiadiazol-5-yl)phenyl]-2-methyl-4-(3H)- quinazolinones; 3-[4-(2-substituted amino-1,3,4-thiadiazol-5-yl)anilino]-2-methyl-4-(3H)- quinazolinones and 3-[(2-substituted amino-1,3,4-thiadiazol-5-yl)methyl]-2-methyl-4(3H)-quinazolinones. The antimicrobial activity of representative compounds of these series as well as of the starting quinazolinone acids was studied.
合成了三类喹唑啉酮衍生物，即：3-[4-(2-取代氨基-1,3,4-噻二唑-5-基)苯基]-2-甲基-4-(3H)-喹唑啉酮；3-[4-(2-取代氨基-1,3,4-噻二唑-5-基)苯胺基]-2-甲基-4-(3H)-喹唑啉酮和3-[(2-取代氨基-1,3,4-噻二唑-5-基)甲基]-2-甲基-4(3H)-喹唑啉酮。研究了这些系列代表性化合物以及起始喹唑啉酮酸的抗菌活性。
