连接足细胞裂孔隔膜与肌动蛋白动力学：nephrin信号复合物的新作用。
Connecting the interpodocyte slit diaphragm and actin dynamics: Emerging role for the nephrin signaling complex.
作者信息
Lehtonen S
机构信息
Haartman Institute, University of Helsinki, Helsinki, Finland.
出版信息
Kidney Int. 2008 Apr;73(8):903-5. doi: 10.1038/ki.2008.69.
PMID:18379524
Abstract
Uchida et al. show in this issue that in rat and human nephrosis, tyrosine phosphorylation of nephrin is reduced, and this is accompanied by a decrease in F-actin in glomeruli. This, together with previous studies, suggests that the nephrin protein complex is a signaling nexus that regulates actin dynamics in podocytes.
摘要
内田等人在本期杂志中指出，在大鼠和人类肾病中，nephrin的酪氨酸磷酸化减少，同时肾小球中的F-肌动蛋白也减少。这与之前的研究共同表明，nephrin蛋白复合物是一个调节足细胞中肌动蛋白动力学的信号枢纽。
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