Schlondorff J
Department of Medicine, Renal Division, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Kidney Int. 2008 Mar;73(5):524-6. doi: 10.1038/sj.ki.5002741.
Regulation and maintenance of the actin cytoskeleton of podocytes has emerged as a critical process for preserving glomerular permselectivity. Signaling through nephrin, a crucial component of the slit diaphragm, can lead to rearrangement of the actin cytoskeleton. Zhu et al. identify phosphoinositide 3-kinase-dependent activation of Akt and Rac as mediators of nephrin-induced actin reorganization, expanding the signaling network linking two of the podocyte's unique structures, its actin cytoskeleton and the slit diaphragm.
足细胞肌动蛋白细胞骨架的调节和维持已成为维持肾小球滤过屏障选择性的关键过程。通过裂孔隔膜的关键组成部分nephrin进行信号传导，可导致肌动蛋白细胞骨架重排。朱等人确定Akt和Rac的磷酸肌醇3激酶依赖性激活是nephrin诱导的肌动蛋白重组的介质，扩展了连接足细胞两个独特结构——其肌动蛋白细胞骨架和裂孔隔膜的信号网络。
